Han Chinese – Communicable Diseases Research

Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trial

Article

Published on 2022-12-012022-10-06
Journal: The Lancet Regional Health - Western Pacific
[Category] 진단,

[키워드] acute respiratory syndrome Administered Adults adverse event AEs age analysis assessment assigned BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine China Chinese clinical trial Complete Completed conducted coronavirus COVID-19 development dose double-blind Efficacy and safety enrolled Follow-up geometric mean titer GMT GMTs Han Chinese healthy immune response immunogenicity immunogenicity endpoint Inc independent individual injection intramuscular Intramuscular injection investigators Laboratory parameters management messenger Messenger RNA Mild moderate mRNA vaccine Neutralising Antibodies neutralising antibody of BNT162b2 participant Participants pharmaceutical Placebo placebo-controlled trial randomisation randomised Randomly reactogenicity receive recipients recruited reduced remained reported resolved Result robust Safety SARS-CoV-2 SARS-CoV-2 variant SCR second dose sera serious AE seroconversion rate severity Shanghai Sponsor statisticians stratified T-cell Response the placebo group Tolerability Treatment Trial utilised vaccination vaccination. vaccine administration were blinded
[DOI] 10.1016/j.lanwpc.2022.100586 PMC 바로가기 [Article Type] Article

From musk to body odor: Decoding olfaction through genetic variation

사향에서 신체 냄새로 : 유전자 변이를 통해 후각을 해독하는

Research Article

Published on 2022-02-032022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Activation Amino acid amino acid substitutions androstenone Anosmia association Body odor change cis-3-hexen-1-ol coding contribute derived allele ENCODE example explicit functional Galaxolide Genetic genetic diversity Genetic variation Han Chinese human body Hypothesis implication IMPROVE individual information input intensity ionone mechanism musk novel association olfactory olfactory receptor OR4D6 OR51B2 OR5A1 OR7D4 Perception performed phenotype populations Previous studies provide receptor receptors reduced replicated reported robust second shown SNP SNPs trans Variation
[DOI] 10.1371/journal.pgen.1009564 PMC 바로가기 [Article Type] Research Article

Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China

C5178a 및 A249d/T6392C/G10310A의 일반적인 mtDNA 변이는 중국 중부의 한족 인구에서 심각한 COVID-19의 위험을 감소시킵니다

Research

Published on 2021-11-012022-09-10
Journal: Military Medical Research
[Category] Fulltext, MERS, 변종, 진단,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analysis association calculate cardiopulmonary diseases categorical variables chest X-ray China CIs common Computed tomography conducted confounding factor continuous variables contribute Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytochrome C cytochrome c oxidase D-loop decrease determine diabetes diagnosed diagnostics disease distribution DNA exclusion criteria Fisher’s exact test Han Chinese healthy control healthy controls hypertension increased risk independent Infection investigated Logistic regression Logistic regression analyses Mitochondria mitochondrial mitochondrial DNA molecular molecular diagnostics MtDNA variations multivariate multivariate logistic regression NADH ND1 ND2 ND3 obesity Odds ratio Odds ratios oxidative phosphorylation oxygen performed Phylogenetic analysis qPCR radiographic examinations reactive oxygen specy reduced risk respiratory Result risk SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus severe COVID-19 Sex shown smoking Student’s t -test subunit supplementary material the healthy variables variant variants Variation Viral viral genome vital role vital roles was used with COVID-19
[DOI] 10.1186/s40779-021-00351-2 PMC 바로가기 [Article Type] Research

Genomic Association vs. Serological Determination of ABO Blood Types in a Chinese Cohort, with Application in Mendelian Randomization

멘델식 무작위 배정에 적용한 중국 코호트에서 ABO 혈액형의 게놈 연관성 대 혈청학적 결정

Article

Published on 2021-06-242022-09-10
Journal: Genes
[Category] MERS, 변종, 유전자 메커니즘,

A false alarm of COVID-19 pneumonia in lung cancer with anti-PD-1 related pneumonitis: a case report and review of the literature

항PD-1 관련 폐렴이 있는 폐암에서 COVID-19 폐렴의 잘못된 경보: 사례 보고 및 문헌 검토

Review

Published on 2021-02-012022-09-10
Journal: Journal of Medical Case Reports
[Category] MERS, 바이오마커, 진단,

[키워드] absorbed Antibiotics Bacterial infection body temperature Case report Cell Chest CT clinical presentation Clinical symptoms clinically clinician close contact Computed tomography contact with COVID-19 COVID-19 epidemic COVID-19 negative COVID-19 pneumonia CRP level diagnosed Diagnosis differential diagnosis Dyspnea epidemiological Features glucocorticoid Ground-glass opacities Han Chinese Immunotherapy indicated injection Laboratory lung lung cancer lung lobe male novel Novel coronavirus pandemic Patient Pneumonia Pneumonitis Prednisolone presenting radiological evidence radiological feature radiological features returned right lung RT-PCR RT-PCR tests subpleural swab sample swab samples Thoracic toxicities Toxicity treated Wuhan
[DOI] 10.1186/s13256-020-02619-y PMC 바로가기 [Article Type] Review

Symptoms and occurrences of narcolepsy: a retrospective study of 162 patients during a 10-year period in eastern China

Article

Published on 2014-06-012023-06-25
Journal: Sleep medicine
[Category] 신종인플루엔자,

[키워드] Cataplexy childhood Excessive weight gain H1N1 pandemic Han Chinese Narcolepsy Precipitating factors.
[DOI] 10.1016/j.sleep.2013.12.012 PMC 바로가기

Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

영장류 게놈에서 새로운 TRIM 유전자에 대한 게놈 저장소 식별

Research Article

Published on 2011-12-012022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] African antiviral gene antiviral genes Author best Biology characterized chromosome chromosome 11 Cluster compared copy number Defense described determine Divergence duplication duplications Evolution expressed found Gene gene cluster Genes Genome genomes Han Chinese HIV Human Human genome human population identification immune system individual innate immune response innate immune system Innate immunity locus majority mechanism MOST natural selection neutralized New pathogen Pathogens positive primate primates question Region reservoir restrict restriction factor retroviral rhesus macaques screened selected Specificities target specificity Tripartite Motif ubiquitin ligase virus recognition viruses young gene
[DOI] 10.1371/journal.pgen.1002388 PMC 바로가기 [Article Type] Research Article